The Tyramine-Excess Neurobiome Phenotype
GoodOnes Neurobiome · Phenotype · NEURO 05 Cool · ~9% of people
In plain terms
Tyramine is a vasoactive amine — it acts on blood vessels and blood pressure and is a classic migraine trigger. In this phenotype the measured tyramine-production capacity reads sharply high (the single most elevated pathway of the group), while butyrate and GABA capacity read low.
That mix tilts toward reflux, vascular reactivity and a metabolic edge.
The move is to suppress the tyramine carriers, rebuild the calm and barrier side, and support the metabolic tilt.
The gut-brain mechanism, in depth
Microbes carrying tyrosine decarboxylase (tyrDC) convert tyrosine into tyramine. Elevated tyramine capacity raises a vasoactive load linked to reflux and migraine, and here it sits alongside low butyrate and GABA — less barrier fuel and less calm signal.
The formula deliberately avoids tyramine-carrier strains (suppress), rebuilds the calm/mood and barrier side, and adds NAD+ for the metabolic tilt; a phage-based suppressor of tyramine producers is on the roadmap.
Your measured signature
Measured functional capacity across the 11 gut-brain pathways — read from targeted gene markers in your sequencing data (not inferred from which microbes are present), and CLR-normalized so pathways compare across people. In this phenotype (measured prevalence 8.8%, n = 369 of ~4,194 clustered samples) the standout readings are:
| Tyramine (tyrDC) | ▲ high | z = +2.02 |
| Polyamine (speA) | ▼ low | z = -0.96 |
| Butyrate — buk route | ▼ low | z = -0.57 |
| Butyrate — but route | ▼ low | z = -0.54 |
| Indole / tryptophan shunt (tnaA) | ▼ low | z = -0.50 |
z = standard deviations from the cohort mean. These clusters come from the measured capacity alone and are not an artifact of sequencing batch (cluster/run agreement ≈ 0).
Signature chart — measured capacity across the 11 gut-brain pathways
How common is this phenotype?
Where your pattern sits among the six measured phenotypes:
Does this sound like you?
Framed as tendencies, not a diagnosis:
In the gut: Reflux, heartburn, frequent bowel movements; sensitivity to aged or fermented foods.
In mood & mind: Vascular headaches or migraine, especially after trigger foods; a 'revved', reflux-linked discomfort.
What the data shows
Across our microbiome dataset (n = 361 in this phenotype), these self-reported conditions were more common in this pattern than at baseline — associations, not a diagnosis:
| Excessive Bowel Movements | 32% report it | OR 1.58 | q = 0.003 |
| Diabetes Type II | 4% report it | OR 3.17 | q = 0.006 |
| Heartburn | 30% report it | OR 1.48 | q = 0.015 |
Shown: associations passing FDR (q < 0.05).
FDR-significant (q<0.05) associations:
What your formula does
The matched formula’s action is SUPPRESS tyramine — crowd out the over-driven producers by competitive exclusion and deliberately leave out the carrier strains.
Neuro-actives layered on the probiotic base:
Take it into your own hands
Your phenotype points to specific, self-directed levers — the “be your own biohacker” angle. None of this is medical treatment; it’s how to feed the pathway the measurement flagged:
- Cut the big tyramine sources: aged cheeses, cured and fermented meats, over-ripe and fermented foods; choose fresh.
- Notice food-triggered headaches and keep a simple trigger log.
- Moderate alcohol (especially aged wines and beers), a common tyramine and vasodilatory load.
- Support the metabolic side with plant fiber and regular movement.
One honest caveat
Your quiz result is a symptom-based pattern, not a verdict — and symptoms are orthogonal to biology, so a measured gut test is what confirms your true phenotype. Everything here is educational and non-therapeutic: formulas potentiate, suppress or support gut-brain pathways; they do not treat, cure or diagnose disease.
Your matched formula
Your result matches the GoodOnes formula built for this gut-brain pattern: Cool. Start there — or confirm your true phenotype first with a measured whole-genome (WGS) test.
See the Cool formula →Confirm it with a test
This result is a symptom-based read — a strong starting point, not a verdict. Symptoms and your actual gut biology are only loosely linked, so the one way to know your true phenotype is to measure it. A whole-genome (WGS) microbiome test reads the real gut-brain gene signatures shown above — the same pathways (butyrate, GABA, serotonin, bile acids) — from your own sequencing data, so your formula is built on measured capacity, not a guess.
Measure your neurobiome →