The Tyramine-Excess Neurobiome Phenotype

GoodOnes Neurobiome · Phenotype · NEURO 05 Cool · ~9% of people

In plain terms

Tyramine is a vasoactive amine — it acts on blood vessels and blood pressure and is a classic migraine trigger. In this phenotype the measured tyramine-production capacity reads sharply high (the single most elevated pathway of the group), while butyrate and GABA capacity read low.

That mix tilts toward reflux, vascular reactivity and a metabolic edge.

The move is to suppress the tyramine carriers, rebuild the calm and barrier side, and support the metabolic tilt.

The gut-brain mechanism, in depth

Microbes carrying tyrosine decarboxylase (tyrDC) convert tyrosine into tyramine. Elevated tyramine capacity raises a vasoactive load linked to reflux and migraine, and here it sits alongside low butyrate and GABA — less barrier fuel and less calm signal.

The formula deliberately avoids tyramine-carrier strains (suppress), rebuilds the calm/mood and barrier side, and layers in a melatonin modulator; a phage-based suppressor of tyramine producers is on the roadmap.

Your measured signature

Measured functional capacity across the 11 gut-brain pathways — read from targeted gene markers in Flore's sequencing data (not inferred from which microbes are present), and CLR-normalized so pathways compare across people. In this phenotype (measured prevalence 8.8%, n = 369 of ~4,194 clustered samples) the standout readings are:

z = standard deviations from the cohort mean. These clusters come from the measured capacity alone and are not an artifact of sequencing batch (cluster/run agreement ≈ 0).

Signature chart — measured capacity across the 11 gut-brain pathways

How common is this phenotype?

Where your pattern sits among the six measured phenotypes:

Does this sound like you?

Framed as tendencies, not a diagnosis:

What the data shows

Across our microbiome dataset (n = 361 in this phenotype), these self-reported conditions were more common in this pattern than at baseline — associations, not a diagnosis:

Shown: associations passing FDR (q < 0.05).

FDR-significant (q<0.05) associations:

What your formula does

The matched formula’s action is SUPPRESS tyramine — crowd out the over-driven producers by competitive exclusion and deliberately leave out the carrier strains.

How this formula is designed

Cool is a suppressor formula. The design idea across the NEURObiotic line is to feed the bacteria, not dose you — pair targeted strains with prebiotic fibers and, where a phenotype calls for it, a tiny modulator boost chosen to work with those strains in the gut. It tempers an over-active pathway by which strains it leaves out and by a small modulator boost chosen to work with the strains it keeps. As a formulation choice, Cool is formulated without tyramine-driving strains. Its prebiotics (green banana powder and turmeric) feed the base strains; the melatonin modulator is a small 2 mg — by design, a subclinical potentiator.

Supplement Facts

Take it into your own hands

Your phenotype points to specific, self-directed levers — the “be your own biohacker” angle. None of this is medical treatment; it’s how to feed the pathway the measurement flagged:

• Cut the big tyramine sources: aged cheeses, cured and fermented meats, over-ripe and fermented foods; choose fresh.
• Notice food-triggered headaches and keep a simple trigger log.
• Moderate alcohol (especially aged wines and beers), a common tyramine and vasodilatory load.
• Support the metabolic side with plant fiber and regular movement.

One honest caveat

Your quiz result is a symptom-based pattern, not a verdict — and symptoms are orthogonal to biology, so a measured gut test is what confirms your true phenotype. Everything here is educational and non-therapeutic: formulas potentiate, suppress or support gut-brain pathways; they do not treat, cure or diagnose disease.

Your matched formula

Your result matches the GoodOnes formula built for this gut-brain pattern: Cool. Start there — or confirm your true phenotype first with a measured whole-genome (WGS) test.